Development of Chem/bio Sensor
Our group has been investigating novel sensing materials and devices to accomplish an ultra-sensitive chem/bio sensors. We have designed conductive and optical nanomaterials (conducting polymer, graphene, CNT, QDs, upconversion) and integrated them into circuit system, including multi-array, micro-fluidic, lateral flow assay, and flexible system by MEMS process. To improve limit detectable level (LOD), we modify the surface of nanomaterials with metal/metal oxide NPs, aptamers, bio-receptors, and Ab/Ag, etc. The sensors exhibited highly sensitive, selective and rapid responses toward target analytes in room temperature. Significantly, it is important for health care/disease diagnosis, environmental monitoring, and E-sense (nose and tongue). They show a potential for advanced technologies, such as wearable devices and IoT (Internet of Things) for the next generation.
Small Molecular Theragnosis
Theragnosis is next-generation healthcare system with therapy and diagnosis. Many researches have been developed for theragnosis using multi-functionalized nanoparticles. However, they showed limitations in-vivo applications because of the size-effect of the particles. Therefore, we have designed small molecules which provide great advantages such as less cytotoxicity, human-implantation and mass-production. In addition, the small molecules also have a fluorescence in range of NIR. The final goal for this project is to create universal theragnosis system for human healthcare.
Interfacing chemistry is one of vast chemistry research. We are researching and developing various nanomaterials based on metal, polymer and semiconductor including quantum dots and metal oxide. Moreover, we investigate the clusters with control over their size and properties. We also synthesize the organic compounds for interacting between these nanomaterials and bioprobes to use a chem/bio-sensor. The strength of our research is ability to facilitate highly stable and sensitive interfacing chemistry by changing the composition of compounds via chemical synthesis, resulting in implementing a required function.
Triplet - Triplet Annihilation Upconversion (TTA-UC)
Amplifying the frequency of noncoherent, low-energy photons through upconversion (UC) presents a unique strategy for enhancing the efficiency Of solar-based technologies, bio-imaging for diagnosis, and energy generating system. Among different approaches to achieve anti-Stokes shifting, UC based on the triplet-triplet annihilation (TTA) mechanism has been considered the most promising due to its unmatched quantum yield (3-40%) at low excitation intensities (1-10 mW/cm2). We have developed the strategy for fabricating TTA-UC nanocapsules, nanoparticles, and nanohybrids including organic compounds and applied for theragnosis and energy harvesting system. Our mission using TTA-UC nanomaterials is to increase the performance of conventional energy and imaging materials.
NanoBio Convergence for Lateral Flow Assay
Lateral Flow Assays (LFAs) are on attractive technology for point-of-care diagnosis which is a point to service patients at the time of care. In addition, LFA technologies have been developed with various systems such as naked-eyes, fluorescence and electrochemical monitoring. Recently, they are extremely considerable interest in the field because of their low-cost, rapid and portable test in blood. Althogh LFA provides high performances, their reliable limit of detection (LOD) is sub ng/mL in blood. To enhance the LOD of LFA system, we are progressing various nanobio convergences for the dramatic signal enhancements. Our achievements will be transfet to the venture companies. The companies will make products and supply for developing conturies which are suffering pain by malaria and so on.
Next-Generation Polymerase Chain Reaction
Polyerase Chain Reaction.(PCR) is a technique based on a molecular diagnosis. The PCRs have been used as a definite diagnosis in hospital for a long time. There are various PCR technologies such as RT-PCR, ISPCR, DDRT-PCR, Lamp PCR. The main mechanism of PCRs is related to thermal cycles and there are many advantages, including rapid, high sensitivity, and selectivity. However, the signal enhancement of PCR still remains as challenge because of monitoring ultra-small amout of target molecules. In our groups, we are developing next-generation PCR system by photonic nanomaterials. The photonic PCR system would provide highly rapid and sensitive results and be also applied for POCT in the field.